منابع مشابه
Have a heart: xenotransplantation, nonhuman death and human distress.
An increasing shortage of transplant donor organs currently results in an escalating number of preventable human deaths. Xenotransplantation. the use of animal organs for transplantation into humans, is now heralded as medicine's most viable answer to the urgent and insurmountable human organ scarcity. Although claimed to be a biomedical prerogative, xenotransplantation is a cultural phenomenon...
متن کاملCarbohydrates in xenotransplantation
The success of allotransplantation has led to an increasing shortage of human organs from deceased donors. This crisis could be resolved by the use of organs from an anatomically suitable animal, such as the pig. The pig and human have, however, been evolving differently for approximately 80 million years, and numerous immunological and physiological barriers have developed that need to be over...
متن کاملRecommendations of the National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group.
The National Heart, Lung, and Blood Institute (NHLBI) recently convened the Heart and Lung Xenotransplantation Working Group to identify hurdles to the clinical application of xenotransplantation, defined as the use of animal organs or tissue for transplantation, and to recommend possible solutions to these problems. The group consisted of experts in xenotransplantation from academia, industry,...
متن کاملSerelaxin, a 'breakthrough' investigational intravenous agent for acute heart failure.
Recombinant relaxin (serelaxin), a breakthrough therapy for acute heart failure.
متن کاملImmunodepletion in xenotransplantation.
Xenograft transplantation is perhaps the most immunologically difficult problem in transplantation today. An overwhelming hyperacute rejection reaction (HAR) occurs within minutes of organ implantation. Preformed antibodies are thought to initiate this process. We used a pig-to-dog renal xenograft transplant model and investigated methods of decreasing the severity of hyperacute rejection. Fema...
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ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2019
ISSN: 1759-5002,1759-5010
DOI: 10.1038/s41569-018-0151-4